Protein Modification Reagents
eMolecules N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester | 2093152-78-2 | MFCD30723293 | 500mg
Broadpharm | N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester | 500mg | 340377010 | BP-23468 | 98.000 | 2093152-78-2 | MFCD30723293 | 503.633 | C25H45NO9
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eMolecules Aminooxy-PEG2-alcohol | 185022-12-2 | MFCD30182047 | 500mg
Broadpharm | Aminooxy-PEG2-alcohol | 500mg | 309208988 | BP-23251 | 98.000 | 185022-12-2 | MFCD30182047 | 121.136 | C4H11NO3
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Cayman Chemical Boc-NH-PEG3-CH2CoH 250mg
A building block; has been used as a linker in the synthesis of PROTACs targeting MEK; has been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and GRPR in tumor tissue in vivo
Medchemexpress LLC T-Boc-N-amido-PEG5-acetic acid | 890152-41-7 | 98.0% | 395.45 g/mol | C17H33NO9 | 250 MG
t-Boc-N-amido-PEG5-acetic acid is a Boc-protected PEG5 linker containing a terminal carboxylic acid and a Boc-protected amine. It is intended for research use and is commonly used as a spacer in PROTAC synthesis and bioconjugation workflows where a hydrophilic, flexible linker is required. The product is offered in multiple package sizes and is characterized by analytical data suitable for synthetic applications.
- Boc-protected amine enabling selective deprotection.
- Terminal carboxylic acid for straightforward amide coupling.
- PEG5 spacer provides a hydrophilic, flexible linkage.
- Reported analytical purity suitable for synthetic use.
- Available in multiple package sizes for research needs.
- Provided for research use only, not for personal use.
Medchemexpress LLC 5,8,11,14,17-pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester | 890152-41-7 | MFCD31656900 | 99.9% | 395.45 g/mol | C17H33NO9 | 25 MG
t-Boc-N-amido-PEG5-acetic acid is a Boc-protected polyethylene glycol (PEG5) linker terminating in a carboxylic acid and bearing a Boc-protected amine. It is designed for use in conjugation chemistries and PROTAC assembly where a hydrophilic, flexible spacer and a carboxylic coupling handle are required. Typical analytical data: HPLC purity 99.91%, molecular formula C17H33NO9, molecular weight 395.45 g/mol.
- Boc-protected amine suitable for selective deprotection
- Five-unit PEG spacer for increased solubility and flexibility
- Terminal carboxylic acid for standard coupling chemistries
- High HPLC purity (reported 99.9%) for reliable synthesis performance
- Compatible with PROTAC linker assembly and conjugation workflows
- Provided in small laboratory quantities for research use
Medchemexpress LLC Cholesterol-PEG-biotin | 2000 (average) | (C2H4O)nC40H66N4O4S | 50 MG
Cholesterol-PEG-Biotin (MW 2000) is a PEGylated lipid conjugate combining a cholesterol anchor with a biotin tag via an approximate 2,000 Da PEG spacer. It is designed to incorporate into lipid bilayers or liposomes and present biotin for high-affinity binding to avidin or streptavidin, enabling surface immobilization, targeted capture, and bioconjugation in biochemical and nanotechnology applications. Supplied as a powder with low-temperature storage recommendations.
- Provides a biotin handle for strong avidin/streptavidin binding.
- Anchors to lipid membranes via a cholesterol moiety.
- Peg spacer increases aqueous solubility and reduces steric hindrance.
- Enables liposome functionalization and surface immobilization.
- Supplied as a powder with recommended low-temperature storage.
Medchemexpress LLC endo-BCN-PEG4-PFP ester | 2904607-26-5 | 95.0% | 607.56 | 100 MG
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, featuring a BCN group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains a BCN group that undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- PROTACs utilize the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
Medchemexpress LLC PROTAC EGFR degrader 7 | 3033297-59-2 | 99.99% | 836.94 | 5 MG
PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13.2 nM. It inhibits NCI-H1975 cells proliferation with an IC50 of 46.82 nM. This product significantly induces apoptosis and G2/M phase arrest in NCI-H1975 cells and shows antitumor activity, making it suitable for non-small cell lung cancer (NSCLC) research. Additionally, it is a click chemistry reagent containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader
- Inhibits NCI-H1975 cells proliferation
- Induces apoptosis and G2/M phase arrest in NCI-H1975 cells
- Shows antitumor activity for non-small cell lung cancer (NSCLC) research
- Click chemistry reagent containing an Alkyne group
Medchemexpress LLC 4,7,10,13-Tetraoxapentadecanoic acid, 15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)- | 518044-36-5 | 99.9% | 250 MG
Mal-PEG4-Boc, a colorless to light yellow oil, is a chemical product identified as HY-130469. It has been thoroughly tested and complies with given specifications, making it suitable for various research applications. The product's molecular formula is C19H31NO8 with a molecular weight of 401.45.
- Colorless to light yellow oil appearance
- Purity of 99.93% (LCMS)
- Chemical structure confirmed by 1H NMR Spectrum and LCMS
- Store at -20°C under nitrogen
- If in solvent, store at -80°C for 6 months or -20°C for 1 month (under nitrogen)
- Intended for research use only
![Medchemexpress LLC Carbamic acid, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | 1263166-93-3 | MFCD19705418 | 97.0% | 324.42 g/mol | C17H28N2O4 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000208868.png-250.jpg)
Medchemexpress LLC Carbamic acid, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester | 1263166-93-3 | MFCD19705418 | 97.0% | 324.42 g/mol | C17H28N2O4 | 25 MG
endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker containing a strained bicyclo[6.1.0]nonyne (BCN) alkyne and a terminal amine. It enables copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) for bioconjugation and is commonly used in PROTAC assembly and linker installation.
- Contains BCN strained alkyne for SPAAC click chemistry.
- Peg2 spacer with a terminal primary amine.
- Purity: 97.0% (HPLC).
- Physical form: colorless to light yellow oil.
- Molecular weight: 324.42 g/mol; formula C17H28N2O4.
- Storage: protect from light; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC DSPE-Mal | 1360858-99-6 | 95.0% | 899.18 g/mol | C48H87N2O11P | 25 MG
DSPE-Mal is a maleimide-functionalized distearoyl phospholipid used to prepare liposomes and lipid-based nanocarriers. The maleimide group enables covalent coupling to thiol-containing molecules for surface functionalization, facilitating targeted delivery and conjugation of peptides, proteins, or other ligands. Supplied as a white to off-white solid for research use.
- Enables covalent coupling to thiol-containing molecules via maleimide-thiol chemistry.
- Facilitates preparation of liposomes and lipid-based nanocarriers.
- Suitable for surface functionalization with peptides, proteins, or targeting ligands.
- Supplied as a white to off-white solid with recommended frozen storage for long-term stability.
- Typical purity ~95.0% and molecular weight ~899.18 g/mol.